Acta Endocrinologica 54:380-384Ħ9-yr-old male with carcinoma of the larynx Vitamin D: 100,000 units/d plus high calcium diet Vitamin D: 200 IU + 1,000 mg calcium/twice dailyĬase 1: 59-yr-old female post-thyroidectomy for 40 yrĬase 2: 71-yr-old female with Paget’s disease Acute toxicity treated with furosemide, calcitonin, and hydrocortisol Loss of bone density and tissue calcification continued despite removal of vitamin D and the pt diedĬonstipation and colic persistent hypertension no renal, cardiac, neurological symptoms noted. Nausea and non-tender lumps over both tibias X-rays showed alternating patterns of increased and decreased bone density. Tx with Ca-free dialysate failed to reduce serum Ca prednisolone for 7 d calcitonin tx stabilized serum Ca Leg pain, cessation of growth resulting from bone resorption serum calcium, accompanied by nausea and vomiting. Response from editor: A toxic dose of more than 200,000 units would only be achieved with ingestion of 2.65 L cod liver oil/dĪll presented with anorexia, weight loss, weakness 2 infants recovered within 6–9 mo following removal of vitamin D 2 infants died: autopsy showed fibrotic changes in vascular tissue, calcification of other tissues was noted, particularly lungīoth cases presented with anorexia, diarrhea, and vomitingĬalcium phosphate crystals in urine bilateral medullary nephrocalcinosis vomiting and lethargy both pts recovered without incidentĮxtreme thirst, hypercalcemia, symptoms of diabetes insipidus Vitamin D: 100,000 IU + cod liver oil-2 T + multivitaminĭaily × 2–3 mo and continued intake of tx vitamin D for 1 yr after hospitalizationīarrueto et al. Vitamin D (Calciferol Tablets B.P.): 1.25 mg.

Infants with hypercalcemia (2 cases with vitamin D toxicity)īesbas et al. Irradited ergosterol containing an estimated 30,000–40,000 IU vitamin

TABLE G-1 Case Studies of Vitamin D Toxicityĭjamil and Tu-Tunji.

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